Synthesis and Evaluation of the Neurotropic Activity of New Tetrahydropyridazin-3-one Derivatives

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

It was established that 4-aryl-4-oxo-2-indol-3-yl butanoic acid and its derivatives upon interaction with hydrazine form 6-aryl-4-[(unsubstituted and substituted) indol-3-yl]-2, 3, 4, 5-tetrahydropyridazin-3-ones, while similarly constructed 4-aryl-4-oxo-2-heterylbutanoic acids under similar conditions are heterocyclized with subsequent azole elimination, resulting in the formation of 6-aryl-2,3-dihydropyridazin-3-ones. The study of the neurotropic activity of new tetrahydropyridazinones derivatives showed that all of the studied substances have anxiolytic action.

Авторлар туралы

R. Khachikyan

The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia

Email: khachikyanraya@gmail.com
ORCID iD: 0009-0006-2014-7861
Армения, Azatutyan Ave. 26, Yerevan, 0014

Z. Hovakimyan

The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia

Email: khachikyanraya@gmail.com
ORCID iD: 0009-0000-1604-5834
Армения, Azatutyan Ave. 26, Yerevan, 0014

G. Panosyan

The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia

Email: khachikyanraya@gmail.com
ORCID iD: 0000-0001-8311-6276
Армения, Azatutyan Ave. 26, Yerevan, 0014

L. Mirzoyan

The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia

Хат алмасуға жауапты Автор.
Email: khachikyanraya@gmail.com
ORCID iD: 0009-0003-4915-9805
Армения, Azatutyan Ave. 26, Yerevan, 0014

R. Paronikyan

The Institut of Organic Chemistry of the Scientific Technological Centre of Organic and Pharmaceutical Chemistry of NA S of Republic of Armenia

Email: khachikyanraya@gmail.com
ORCID iD: 0000-0002-3845-6324
Армения, Azatutyan Ave. 26, Yerevan, 0014

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