ACUTE TOXICITY OF THE MINERAL COMPLEX BASED ON NANOPOWDERS OF IRON, COPPER AND ZINC AFTER A SINGLE INTRAPERITONEAL INJECTION

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Abstract

An injection form of the mineral complex consisting of a mixture of iron, zinc and copper nanopowders has been proposed. According to the results of studies the injection form of the drug based on metal nanopowders belongs to the V-VI class of practically non-toxic, relatively harmless drugs by Hodge and to the 5th class of toxicity in accordance with GOST 32644-2014. 

About the authors

E. Yu. Andreeva

N.I. Vavilov Saratov State Agrarian University.

Author for correspondence.
Email: fake@neicon.ru
410012, Saratov. Russian Federation

T. N. Rodionova

N.I. Vavilov Saratov State Agrarian University.

Email: fake@neicon.ru
410012, Saratov. Russian Federation

D. V. Gorbunov

Institute of Toxicology of the Federal Medical and Biological Agency.

Email: fake@neicon.ru
192019, Saint-Petersburg. Russian Federation

M. P. Marinicheva

N.I. Vavilov Saratov State Agrarian University.

Email: fake@neicon.ru
410012, Saratov. Russian Federation

References

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  2. Alyautdin R.N., Romanov B.K. Recommendations for the evaluation of the safety of drugs containing nanoparticles. Safety and risk of pharmacotherapy. 2015; 5: 10-21. (in Russian)
  3. Guidelines for conducting preclinical studies of drugs. Part one. Edited by Mironov A.N. - M .: Grief and K, 20- 944 p. (in Russian)
  4. GOST 32644-2014 Test methods for the effects of chemical products on the human body. Acute oral toxicity - method for determining the class of acute toxicity, 2015. (in Russian)
  5. Reznichenko L.S., Dybkova S.N., Doroshenko A.M., Chekmani I.S., Ulberg Z.R. Synthesis of iron nanoparticles and characterization of their biosafety. Bulletin of problems of biology and medicine. 2014; 3 (2): 319-323. (in Russian)
  6. Prozorovsky V.B. Statistical processing of pharmacological research results. Psychopharmacology and biological narcology. 207 (3): 2090-2120. (in Russian

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Copyright (c) 2018 Andreeva E.Y., Rodionova T.N., Gorbunov D.V., Marinicheva M.P.


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