NEUROTOXICOLOGICAL PROPERTIES OF THE COMPOUND AV-19 FOR PROPHYLAXIS AND TREATMENT OF COMPLICATIONS OF DIABETES MELLITUS

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The article presents the results of a study of the neurotoxicological profile of the new compound AB-19, acting on collagen glycation end products (AGE) and their receptors (RAGE), for the prevention and treatment of diabetes complications. The multi-test method «S. Irwin» was used. The test results were evaluated in parallel groups receiving the substance in doses starting with the average effective dose (ED50) and with a multiple increase by 5, 10, 20 and 50 times. It was found that the compound AB-19 in doses of 20, 100 and 200 mg / kg does not affect the functional and behavioral status of animals. However, with an increase to 400 mg / kg, typical manifestations of intoxication were observed: a decrease in muscle tone, hypothermia, sedation, tachypnea. As a result of the study, it was revealed that the neurotoxicological properties of the compound AB-19 are characterized by dose-dependent activity. A minimum toxic dose of 400 mg / kg ≤ Tdmin ≤ 1000 mg / kg was also indicated.

作者简介

D. Maltsev

Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center

编辑信件的主要联系方式.
Email: maltsevdmitriy@rambler.ru

Maltsev Dmitriy Vasil’evich

400131, Volgograd

400131, Volgograd

俄罗斯联邦

A. Spasov

Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center

Email: aspasov@mail.ru
Spasov Aleksandr Alekseevich

400131, Volgograd

400131, Volgograd

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V. Kosolapov

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: vad-ak@mail.ru

Kosolapov Vadim Anatol’evich

400131, Volgograd

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K. Sultanova

Volgograd State Medical University, Ministry of Health of the Russian Federation; Volgograd Medical Scientific Center

Email: sultanova.pharma@gmail.com

Sultanova Kira Timurovna

400131, Volgograd

400131, Volgograd

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M. Miroshnikov

Volgograd State Medical University, Ministry of Health of the Russian Federation

Email: mihailmiroshnikov@mail.ru

Miroshnikov Mikhail Vladimirovich

400131, Volgograd

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S. Kotovskaya

Ural Federal University named after the fi rst President of Russia B.N. Yeltsin

Email: s.k.kotovskaya@urfu.ru

Kotovskaya Svetlana Konstantinovna

620002, Yekaterinburg

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I. Sapozhnikova

Ural Federal University named after the fi rst President of Russia B.N. Yeltsin

Email: i.m.sapozhnikova@urfu.ru

Sapozhnikova Irina Mikhailovna

620002, Yekaterinburg

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V. Rusinov

Ural Federal University named after the fi rst President of Russia B.N. Yeltsin

Email: v.l.rusinov@urfu.ru

Rusinov Vladimir Leonidovich

620002, Yekaterinburg

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参考

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版权所有 © Maltsev D.V., Spasov A.A., Kosolapov V.A., Sultanova K.T., Miroshnikov M.V., Kotovskaya S.K., Sapozhnikova I.M., Rusinov V.L., 2020


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