Biomarkers of work-related endothelial dysfunction in employees of ore-dressing production occupied in conditions of long-term noise exposure

The article demonstrates the methodical approach to the justification of biomarkers of adverse effects (for example, endothelial dysfunction) in workers of sylvinite ore-dressing production occupied in conditions of the long-term noise exposure at the level of 85-95 dBA. The methodology testing revealed that the professional risk in workers of basic specialties is estimated from mild to unbearable by the criterion class of working conditions (3.1.-3.3.). Hypertensive heart disease is a most often occupationally conditioned disorder (RR = 8.69, DI = 2.53-29.83; etiological fraction (EF) = 88.49%). Endothelial dysfunction, pathogenetically related to the development of hypertension, has a high degree of occupational conditionality in terms of a reduced level of K-brachial artery sensitivity to stress and a reduced level of the relative increase in the brachial artery diameter. Biomarkers of endothelial dysfunction (in terms of reducing the relative increase in the brachial artery diameter) are elevated serum levels of TSH, MDA, IL-10, lipoprotein (a) in respect to the physiological norms. The reasonable biomarkers of negative effect allow to expand the evidence base of industrial conditioning of disease process in workers at individual and group level at the determined noise exposure.

производственные факторы риска, шум, биомаркеры, негативные эффекты, эндотелиальная дисфункция, причинно-следственные связи, occupational risk factors, noise, biomarkers, negative effects, endothelial dysfunction, causal relationships