Study of the skin-resorptive effect of ethyl alcohol on immature rats and their offspring

Zukhra K. Shaykhutdinova; Шайхутдинова Зухра Камиловна; Alexander S. Morozov; Морозов Александр Сергеевич; Galina P. Pankratova; Панкратова Галина Павловна; Marina V. Bidevkina; Бидевкина Марина Васильевна; Margarita V. Matrosenko; Матросенко Маргарита Владимировна; Arina I. Vinogradova; Виноградова Арина Игоревна; Regina I. Latipova; Латипова Регина Искандаровна; Natalya S. Beloyedova; Белоедова Наталья Сергеевна; Mikhail A. Poroshin; Порошин Михаил Андреевич; Yulia S. Volkova; Волкова Юлия Сергеевна; Tatiana A. Sinitskaya; Синицкая Татьяна Алексеевна; Vitaly V. Safandeev; Сафандеев Виталий Васильевич

doi:10.47470/0016-9900-2025-104-3-358-364

Study of the skin-resorptive effect of ethyl alcohol on immature rats and their offspring

作者: Shaykhutdinova Z.K.¹, Morozov A.S.¹, Pankratova G.P.¹, Bidevkina M.V.¹, Matrosenko M.V.¹, Vinogradova A.I.¹, Latipova R.I.¹, Beloyedova N.S.¹, Poroshin M.A.¹, Volkova Y.S.¹, Sinitskaya T.A.¹, Safandeev V.V.¹
隶属关系:
1. Federal Scientific Center of Hygiene named after F.F. Erisman
期: 卷 104, 编号 3 (2025)
页面: 358-364
栏目: PREVENTIVE TOXICOLOGY AND HYGIENIC STANDARTIZATION
##submission.datePublished##: 15.12.2025
URL: https://freezetech.ru/0016-9900/article/view/678772
DOI: https://doi.org/10.47470/0016-9900-2025-104-3-358-364
EDN: https://elibrary.ru/txmwjg
ID: 678772

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Introduction. To prevent the transmission of infectious diseases in everyday life activities, it is crucial to ensure the conditions for hand skin disinfection in preschool and school-age children to be safe. Due to the anatomo-physiological features of the skin structure and the weak protective barrier in children, it is essential to assess the toxicity of skin antiseptics intended for hygienic treatment of hands on an adequate model. To date, the most promising group of antiseptics is that of alcohol-containing skin antiseptics, which have the widest spectrum of antimicrobial activity and allow the quick and high-quality treatment of the skin.
Objective. To study the toxic effect of ethyl alcohol under conditions of repeated application to the skin of immature white rats and its subsequent effect on the offspring of these rats.
Materials and Methods. Toxicity and danger studies were conducted on forty immature white mongrel rats (n = 10 females and 10 males per group) using a 70% ethyl alcohol solution. The subsequent study evaluated the long-term effects on their offspring. The functional state of the liver and kidneys was evaluated in animals, biochemical examination of blood serum and urine was carried out. Additionally, the ethanol content in the blood in rats was quantified following a single administration of ethanol into the stomach, application to the skin, and tail. The rate of formation of sensory-motor reflexes was determined in the offspring of experimental rats.
Results. The results demonstrated that there were changes in the functional state of the nervous system in males and females, as well as disturbances in metabolic processes in the liver of rats, which were manifested in changes in some indicators (carbohydrate metabolism, creatinine synthesis). The study of the formation of sensory-motor reflexes in offspring did not reveal any differences between the control and experimental groups. At a single application of 70% ethanol to the skin of sexually mature rats, the ethanol content in blood was determined one hour after its application, at intragastric administration – one hour, two, and three hours later.
Limitations. There is a paucity of data on rat skin histology, no method to enhance transdermal delivery of topical antiseptics was considered, and the mechanisms of interaction of ethanol-containing antiseptics with the carrier, vesicles, and particles (if any) were not investigated. Furthermore, the modification of the stratum corneum of the epidermis, energetic methods, and methods of bypassing the stratum corneum were not studied.
Conclusion. The results of the conducted studies indicate 70% ethyl alcohol to have a skin-resorptive effect on immature white mongrel rats. Therefore, it is not recommended to include ethyl, isopropyl, and propyl alcohols in the formulations of skin antiseptics intended for children under 12 years of age.