THE INFLUENCE OF SMALL DOSES OF THE HERBICIDE 2,4-DICHLOROPHENOXYACETIC ACID ON THE BODY WEIGHT OF ANIMALS UNDER THE DIET WITH NORMAL OR HIGH CALORIE
- 作者: Karmanova D.S.1, Chesnokova L.A.1, Krasikov S.I.1
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隶属关系:
- Orenburg State Medical University
- 期: 卷 96, 编号 3 (2017)
- 页面: 287-288
- 栏目: EXPERIMENTAL INVESTIGATIONS
- ##submission.datePublished##: 21.10.2020
- URL: https://freezetech.ru/0016-9900/article/view/640644
- DOI: https://doi.org/10.47470/0016-9900-2017-96-3-287-288
- ID: 640644
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详细
There was studied the effect of 6-weeks intake of small doses of the herbicide 2,4-DA on the body weight of animals. The consumption of water containing the herbicide in a concentration of 0.5 MPC was shown to have led to the greater gain of the body weight in experimental rats in comparison with the control. Simultaneously there was noted the gain of the mass of epididymal fat and increase in the concentration of leptin. This effect was more pronounced in rats treated with 2,4-DA, under the diet with high caloric content. The results obtained are likely to be associated with the disrupting action of the herbicide, leading, in particular, to the disturbance of the regulatory function of the thyroid gland and insulin resistance.
作者简介
D. Karmanova
Orenburg State Medical University
编辑信件的主要联系方式.
Email: daryakarmanova@mail.ru
俄罗斯联邦
L. Chesnokova
Orenburg State Medical University
Email: noemail@neicon.ru
俄罗斯联邦
S. Krasikov
Orenburg State Medical University
Email: noemail@neicon.ru
俄罗斯联邦
参考
- Casals-Casas C., Desvergne B. Endocrine disruptors: from endocrine to metabolic disruption. Annu. Rev. Physiol. 2011; 73: 135-62.
- Woods S.C., D’Alessio D.A. Central control of body weight and appetite. J. Clin Endocrinol. Metab. 2008; 93(11 Suppl. 1): S37-50.
- Chinalia F.A., Regali-Seleghin M.H., Correa E.M. 2,4-D Toxicity; Cause, Effect and Control. Terr. Aquat. Environ. Toxicol. 2007; 1(2): 24-33.
- WHO. 2,4-Dichlorophenoxyacetic Acid (2,4-D). Guidelines for Drinking-Water Quality. 2nd ed. Geneva; 1998.
- Welshons W.V., Thayer K.A., Judy B.M., Taylor J.A., Curran E.M., vom Saal F.S. 2003. Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. Environ. Health Perspect. 111(8): 994-100.
- Joosten H.F., van der Kroon P.H. Enlargement of epididymal adipocytes in relation to hyperinsulinemia in obese hyperglycemic mice (ob/ob). Metabolism. 1974. 23(1): 59-66.
- Шакирова Г.Р., Имашев А.В., Муфазалова Н.А. Морфофункциональное состояние щитовидной железы при воздействии гербицида 2,4-ДАипоследующей коррекции токоферолом и миелопидом. Успехи современного естествознания. 2006; (3): 87
- Roden M., Price T.B., Perseghin G., Petersen K.F., Rothman D.L., Cline G.W. et al. Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 1996; 97(12): 2859-65
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