A systems approach to carcinogenic risk assessment and management for metallurgical workers employed in various blister copper production processes
- 作者: Adrianovsky V.I.1,2, Kuzmina E.A.1, Zlygosteva N.V.1, Boyarsky A.P.1, Lipatov G.Y.1,2
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隶属关系:
- Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
- Ural State Medical University
- 期: 卷 96, 编号 12 (2017)
- 页面: 1161-1166
- 栏目: OCCUPATIONAL HEALTH
- ##submission.datePublished##: 21.10.2020
- URL: https://freezetech.ru/0016-9900/article/view/640713
- DOI: https://doi.org/10.47470/0016-9900-2017-96-12-1161-1166
- ID: 640713
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全文:
详细
The paper presents results of the application of the system approach to carcinogenic risk assessment and management based on the identification carcinogens, prediction carcinogenic effects and rationale for targeted preventive and curative measures. Evidence from metallurgical shops where various blister copper production processes are used regardless of the existing smelting technologies shows the risk of cancer to be Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeingeptable even when the working conditions are classified as permissible (class 2) in terms of chemical factors. The highest carcinogenic risk values are observed for occupations with workplaces characterized by a significant release of dust, arsenic being the main risk contributor. In cases of the blast furnace and reverberatory furnace smelting, carcinogenic risks for workers with a 25-year length of employment exceed the permissible level by 17.6 and 28.8 times, respectively, and in the case of bath smelting, carcinogenic risks exceed the permissible level by 5.1 times. The maximum length of employment for bath smelting shop workers amounts to 5.14 years, being by 1.42 and 0.89 years higher than that for the blast furnace and reverberatory furnace smelting shop workers, respectively. The observed cancer mortality rates exceed significantly the expected mortality rates for the tumor of all sites in cases of combined and respiratory cancers. The highest cancer mortality rates were recorded for batch loaders (60%) and smelter (40%) with the highest predicted carcinogenic risk values. Cancer-specific marker levels higher normal ones were detected in 73% of workers from the increased individual carcinogenic risk group. The proposed system approach to carcinogenic risk assessment and management will make it possible to try out components of the risk-based approach in the supervisory activities at industrial facilities with exposure to carcinogens, to establish the acceptable risk levels depending on the length of employment, identify the priority carcinogens; it will also allow indicating a rationale for additional testing for occupational carcinogenesis predictors as part of routine medical examination procedures and to develop preventive measures against key risk factors.
作者简介
Vadim Adrianovsky
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing; Ural State Medical University
编辑信件的主要联系方式.
Email: noemail@neicon.ru
ORCID iD: 0000-0001-7754-8910
MD, PhD, Senior Researcher of the Epidemiology and Cancer Prevention Laboratory, the Hygiene and Population-Based Disease Prevention Department, Medical Research Center for Prophylaxis and Health Protection of Industrial Workers; Associate Professor, Hygiene and Occupational Diseases Department, Ural State Medical University.
e-mail: adrianovsky@k66.ru
俄罗斯联邦E. Kuzmina
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: noemail@neicon.ru
ORCID iD: 0000-0002-0723-8674
俄罗斯联邦
N. Zlygosteva
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: noemail@neicon.ru
俄罗斯联邦
A. Boyarsky
Email: noemail@neicon.ru
俄罗斯联邦
G. Lipatov
Ekaterinburg Medical Research Center for Prophylaxis and Health Protection of Industrial Workers, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing; Ural State Medical University
Email: noemail@neicon.ru
ORCID iD: 0000-0002-6982-7933
俄罗斯联邦
参考
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