Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study

D. A. Poletaeva; Полетаева Д. А.; I. I. Faingold; Файнгольд И. И.; Yu. V. Soldatova; Солдатова Ю. В.; A. V. Smolina; Смолина А. В.; M. A. Savushkin; Савушкин М. А.; N. A. Sanina; Санина Н. А.; S. M. Aldoshin; Алдошин С. М.

doi:10.31857/S0044453723050217

Interaction between Iron Nitrosyl Complexes and Phosphatidylcholine Membranes: A Fluorescence Study

Авторлар: Poletaeva D.A.¹, Faingold I.I.¹, Soldatova Y.V.¹, Smolina A.V.¹, Savushkin M.A.², Sanina N.A.¹^,3, Aldoshin S.M.¹
Мекемелер:
1. Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
2. Faculty of Chemistry, Moscow State University
3. Medicinal Chemistry Research and Educational Center
Шығарылым: Том 97, № 5 (2023)
Беттер: 617-623
Бөлім: ФИЗИКА И ХИМИЯ ЭЛЕМЕНТАРНЫХ ХИМИЧЕСКИХ ПРОЦЕССОВ
##submission.dateSubmitted##: 27.02.2025
##submission.datePublished##: 01.05.2023
URL: https://freezetech.ru/0044-4537/article/view/668734
DOI: https://doi.org/10.31857/S0044453723050217
EDN: https://elibrary.ru/HLWJUG
ID: 668734

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Аннотация

Fluorescent probes: 8-anilino-1-naphthalenesulfonate (ANS), eosin Y, and pyrene were used to study the interaction between liposomes and three nitrosyl iron complexes that are promising anti-inflammatory agents and cardioprotectors. It was shown that the studied complexes compete with ANS molecules for the bonding sites in a bilayer of liposomes. The incorporation of the complexes into the lipid bilayer was also studied according to the quenching of eosin Y and pyrene fluorescence. The data suggest that iron nitrosyl complexes interact with the phospholipids headgroups and can penetrate deeper into the hydrophobic center of a lipid bilayer, where they affect the packing of fatty acid chains. The pronounced membranotropic properties of the complexes correlated with their ability to inhibit lipid peroxidation. Complexes with high constants of pyrene bonding are the most effective antioxidants.

Негізгі сөздер

nitrosyl iron complexes, NO donors, membrane liposomes, fluorescent probes, lipid peroxidation

Әдебиет тізімі

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