Synthesis of Phosphoisosteres of Amyloid Dipeptide Components

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Resumo

A simple and effective method was proposed for the synthesis of new phosphinic peptides in free form, structural isosteres of the dipeptide components of beta-amyloid (Aβ42), potential inhibitors of zinc-metalloproteinases.

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Sobre autores

S. Golovash

Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences

Email: rvalery@dio.ru
Rússia, Chernogolovka

D. Ivanov

Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences

Email: rvalery@dio.ru
Rússia, Chernogolovka

A. Borodachev

Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences

Email: rvalery@dio.ru
ORCID ID: 0000-0002-3458-5129
Rússia, Chernogolovka

V. Shestov

Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences

Email: rvalery@dio.ru
Rússia, Chernogolovka

M. Dmitriev

Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences

Email: rvalery@dio.ru
ORCID ID: 0000-0001-8870-195X
Rússia, Chernogolovka

V. Ragulin

Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences

Autor responsável pela correspondência
Email: rvalery@dio.ru
ORCID ID: 0000-0002-3967-1034
Rússia, Chernogolovka

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