Available method for the synthesis of E-N-substituted-2-diphenylphosphorylaziridines

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Abstract

An available method for the synthesis of 2-diphenylphosphoryl- N -substituted aziridines with high yields has been developed by the interaction of (1,2-dibromoethyl)(diphenyl)phosphine oxide with a number of primary amines, in particular, methyl-, ethyl-, isopropyl-, tert -butyl-, cyclohexyl- and benzylamines at room temperature in the presence of sodium hydroxide. The antibacterial activity of obtained compounds was studied.

About the authors

A. S. Bichakhchyan

Institute of Organic Chemistry, Scientific Technological Centre of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

Email: arpenikb@mail.ru

L. V. Derdzyan

Institute of Organic Chemistry, Scientific Technological Centre of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

A. S. Poghosyan

Institute of Organic Chemistry, Scientific Technological Centre of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

H. A. Panosyan

Molecule Structure Research Center NAS RA

A. G. Arakelyan

Institute of Organic Chemistry, Scientific Technological Centre of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

H. M. Stepanyan

Institute of Organic Chemistry, Scientific Technological Centre of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

R. E. Muradyan

Institute of Organic Chemistry, Scientific Technological Centre of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

G. Ts. Gasparyan

Institute of Organic Chemistry, Scientific Technological Centre of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia

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