Reaction of Tetrahydropyrimidine-2(1H)-thione Derivatives with Thiolated Acid Hydrazides as a Method of Synthesis of Biologically Active Ligands of Gold Glyco-Nanoparticles

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Аннотация

The reaction of 4-hydroxy-1-phenyl-6-methyltetrahydropyrimidine-2(1H)-thione with 6-mercaptohexanoic and lipoic (thioctic) acids hydrazides in yields of 60–75% to form 4-[ω-(mercaptoacyl)hydrazino]-tetrahydropyrimidine-2(1H)-thiones as a promising сo-ligands for the preparation of gold glyco-nanoparticles for biomedical purposes.

 

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Авторлар туралы

A. Ershov

Institute of Macromolecular Compounds of the Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: ershov305@mail.ru
ORCID iD: 0000-0002-2266-4380
Ресей, Bolshoi pr., 31, St. Petersburg, 199004

I. Lagoda

State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation

Email: ershov305@mail.ru
ORCID iD: 0000-0002-3906-2909
Ресей, Lesoparkovaya ul., 4, St. Petersburg, 195043

A. Martynenkov

Institute of Macromolecular Compounds of the Russian Academy of Sciences

Email: ershov305@mail.ru
ORCID iD: 0000-0002-0951-1451
Ресей, Bolshoi pr., 31, St. Petersburg, 199004

A. Batyrenko

State Research Testing Institute of Military Medicine, Ministry of Defense of the Russian Federation

Email: ershov305@mail.ru
ORCID iD: 0000-0001-9688-3650
Ресей, Lesoparkovaya ul., 4, St. Petersburg, 195043

Әдебиет тізімі

  1. Sanchez-Sancho F., Escolano M., Gavina D., Csaky A.G., Sanchez-Rosello M., Diaz-Oltra S., del Pozo C. Pharmaceuticals. 2022, 15, 948. doi: 10.3390/ph15080948
  2. Amina S.J., Guo B. Inter. J. Nanomed. 2020, 15, 9823–9857. doi: 10.2147/ijn.s279094
  3. Nanobiomaterials in Cancer Therapy: Applications of Nanobiomaterials. Ed. A.M. Grumezescu. Amsterdam, Boston et al.: William Andrew, Elsevier, 7, 2016. doi: 10.1016/B978-0-323-42863-7.00002-5
  4. Engineered Carbohydrate-Based Materials for Biomedical Applications: Polymers, Surfaces, Dendrimers, Nanoparticles, and Hydrogels. Ed. R. Narain. New Jersey: John Wiley & Sons, 2011. doi: 10.1002/9780470944 349.ch6
  5. Ершов А.Ю., Мартыненков А.А., Лагода И.В., Батыренко А.А., Драчев И.С., Якунчикова Е.А., Федорос Е.И., Круглов С.С., Копаница М.А., Якиманский А.В. ЖОХ. 2022, 92, 788–798. [Ershov A.Yu., Martynenkov A.A., Lagoda I.V., Batyrenko A.A., Drachev I.S., Yakunchikova E.A., Fedoros E.I., Kruglov S.S., Kopanitsa M.A., Yakimansky A.V. Russ. J. Gen. Chem. 2022, 92, 850–859.] doi: 10.1134/S1070363222050140
  6. Алексеев В.В., Якимович С.И., Зерова И.В., Егорова М.Б., Синкконен Я. ХГС. 2014, 10, 1606–1617. [Alekseyev V.V., Yakimovich S.I., Zerova I.V., Egorova M.B., Sinkkonen J. Chem. Heterocycl. Com. 2014, 49, 1490–1499.] doi: 10.1007/s10593-014-1400-z

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