MATERIALS FOR SUBSTANTIATION OF HYGIENIC STANDARDS FOR BIS (TRIPHENYLSILYL)CHROMATE IN VARIOUS ENVIRONMENTAL MEDIA

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Abstract

In experiments on white rats, the main toxicometric parameters of bis(triphenylsilyl) chromate were established at single and repeated stomach and intraperitoneal administration. The character of the biological action of bis(triphenylsilyl) chromate with different delivery paths into the organism and levels of effective doses/concentrations are analogous to those of hexavalent chromium compounds. Based on these conclusions, TLV/TWA (Threshold limit value/time-weighted average)) of bis(triphenylsilyl) chromate in occupational air, tentative safe exposure level (TSEL) in atmospheric air of residential settings, tentative permissible levels (TPL) in water of water reservoirs were substantiated and approved at the level of magnitudes adopted for hexavalent chromium compounds in RF.

About the authors

Marina Vasil’evna Bidevkina

Federal Budgetary Science Institution «Scientific Research Disinfectology Institute», Rospotrebnadzor

Author for correspondence.
Email: noemail@neicon.ru

Кандидат медицинских наук, заведующая лаборатории токсикологии дезинфекционных средств ФБУН «Научно-исследовательский институт дезинфектологии» Роспотребнадзора, 117246, г. Москва,

e-mail: BidevkinaMV@niid.ru

Russian Federation

Nikolaj Georgievich Ivanov

State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical
University»

Email: noemail@neicon.ru

Доктор медицинских наук, профессор, заведующий отделом токсикологии НИИФПБИ (фундаментальных и прикладных биомедицинских исследований) РНИМУ им. Н.И. Пирогова, 117997, г. Москва

Russian Federation

Elena Borisovna Guglja

State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical
University»

Email: noemail@neicon.ru

Кандидат химических наук, старший научный сотрудник отдела токсикологии НИИФПБИ (фундаментальных и прикладных биомедицинских исследований) РНИМУ им. Н.И. Пирогова, 117997, г. Москва

e-mail: let@rsmu.ru

Russian Federation

Jemilija Grigor’evna Skrjabina

State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical
University»

Email: noemail@neicon.ru

Кандидат медицинских наук, старший научный сотрудник отдела токсикологии НИИФПБИ (фундаментальных и прикладных биомедицинских исследований) РНИМУ им. Н.И. Пирогова, 117997, г. Москва

e-mail: let@rsmu.ru

Russian Federation

Natalia Ivanovna Sheina

State Budgetary Educational Institution of Higher Professional Education «N.I. Pirogov Russian National Research Medical
University»

Email: noemail@neicon.ru

Доктор биологических наук, доцент, профессор кафедры гигиены ГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова», 117997, г. Москва

e-mail: let@rsmu.ru

Russian Federation

References

  1. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Chromium. U.S. Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA. 1998.
  2. Marouani N., Tebourbi O., Mahjoub S., Yacoubi M.T., Sakly M., Benkhalifa M., Rhouma K.B. Effects of hexavalent chromium on reproductive functions of male adult rats. Reprod Biol. 2012 Jul;12(2):119-33.
  3. Marouani N., Tebourbi O., Mokni M., Yacoubi M.T., Sakly M., Benkhalifa M., Ben Rhouma K. Embryotoxicity and fetotoxicity following intraperitoneal administrations of hexavalent chromium to pregnant rats. Zygote. 2011 Aug;19(3):229-35.
  4. Thompson C.M., Proctor D.M., Suh M., Haws L.C., Kirman C.R., Harris M.A. Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans. Crit Rev Toxicol. 2013 Mar;43(3):244-74
  5. Bagchi D., Stohs S.J., Downs B.W., Bagchi M., Preuss H.G. Cytotoxicity and oxidative mechanisms of different forms of chromium. Toxicology. 2002 Oct 30;180(1):5-22.
  6. Xie Y., Zhong C., Zeng M., Guan L., Luo L. Effect of hexavalent chromium on electron leakage of respiratory chain in mitochondria isolated from rat liver. Cell Physiol Biochem. 2013;31(2-3):473-85.
  7. Guidelines for the formulation of research to substantiate the sanitary standards of harmful substances in theair of working zone. № 2163-80. - M., 1980. - 20. (in Russian).
  8. Guidance on substantiation of hygienic standards in water of water bodies. No. 2.1.5.720-98.- M., 1998 - 55. (in Russian).
  9. Requirements for the production of experimental studies for substantiation of the maximum permissible concentrations of industrial allergens in the air of working zone and atmosphere. No. 1.1.578-96.-M., 1996. - 24. (in Russian).

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Copyright (c) 2015 Bidevkina M.V., Ivanov N.G., Guglja E.B., Skrjabina J.G., Sheina N.I.


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