EVALUATION OF TOXICITY OF 3-BROMO AMINOBENZENE SULFATE AS A BASIS FOR PREDICTION OF OCCUPATIONAL RISK TO HEALTH

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Abstract

Toxic properties of 3-bromo aminobenzene sulfate were studied for its hygiene regulation in workplace air. LD50 of the substance administrated abdominally to female rats and male and female mice are respectively 1120, 2000 and 2973 mg/kg (III hazard class according to GOST 12.1.007-76). Significant differences in species and sex sensitivity of animals to the substance are not found: the coefficient of species differences is 2.7; coefficient of sex sensitivity is 1.5. It poses no local irritation to the skin and has a moderate irritant effect on the eye mucous membranes. Sensitizing effect is not revealed. It has a weak ability to cumulation: Ccum>5.

In a sub-acute experiment selective lesion of red blood cells (methemoglobinemia, sulfhemoglobinemia) with the development of hemolytic anemia of regenerative nature was observed, as well as damage to the liver and kidneys. The threshold of acute inhalation action is 22.2 mg/m3.

The tentative safe exposure level in the workplace air is 1 mg/m3.

About the authors

Nina Andreevna Martynova

Federal State Budgetary Institution «Research Institute for Complex Problems of Hygiene and Occupational Diseases» , Siberian Branch of the Russian Academy of Medical Sciences

Author for correspondence.
Email: noemail@neicon.ru

Кандидат медицинских наук, старший научный сотрудник лаборатории прикладных гигиенических исследований ФГБУ «Научно-исследовательский институт комплексных проблем гигиены и профессиональных заболеваний» Сибирского отделения РАМН, 654041, г. Новокузнецк

e-mail: ecologia_nie@mail.ru

Russian Federation

Larisa Gennadjevna Gorokhova

Federal State Budgetary Institution «Research Institute for Complex Problems of Hygiene and Occupational Diseases» , Siberian Branch of the Russian Academy of Medical Sciences

Email: noemail@neicon.ru

Кандидат биологических наук, старший научный сотрудник лаборатории экспериментальных гигиенических исследований ФГБУ «Научно-исследовательский институт комплексных проблем гигиены и профессиональных заболеваний» Сибирского отделения РАМН, 654041, г. Новокузнецк

e-mail: ponomarikova@mail.ru

Russian Federation

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