ASSESSMENT OF TOXICITY AND HAZARD OF TECHNICAL PRODUCT OF TRIAZINONE’S DERIVATIVE

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Experimental assessment of toxicity and hazard of technical product of triazinone’s derivative at its peroral administration into warm-blooded animals’ bodies (male rats) has been conducted to determine the character of the substance biological action. Its acute peroral toxicity was at the level of LD50 -1693 ± 470 mg/kg of body weight, hazard class – 4 according to Hygienic Classification of Pesticides (Sanitary Rules & Standards 1.2.2584-10). Effective dose was 62.5 mg/kg b.w., non-effective dose (NOEL) was 12.5 mg/kg b.w. ADI was 0.1 mg/kg b.w.

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V. Rakitskii

F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor

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Email: pesticidi@yandex.ru

Rakitskii Valery Nikolaevich 

141014, Mytishchi, Moscow Region,

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T. Еpishina

F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor

Email: pesticidi@yandex.ru

Epishina Tatiana Mihailovna

141014, Mytishchi, Moscow Region,

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E. Chkhvirkiya

F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor

Email: pesticidi@yandex.ru

Chkhvirkiya Elena Grigor'evna

141014, Mytishchi, Moscow Region,

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T Sinitskaya

F.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor

Email: pesticidi@yandex.ru

Sinitskaya Tat'yana Alekseevna

141014, Mytishchi, Moscow Region,

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Е. Mukhina

.F. Erisman Federal Research Center of Hygiene of Rospotrebnadzor

Email: pesticidi@yandex.ru

Mukhina Ekaterina Aleksandrovna

141014, Mytishchi, Moscow Region,

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参考

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  2. Sinitskaya T.A., Malinovskaya H.H.Toxicological-hygienic justification of the acceptable daily intake of acetamiprid. М. Gigiena and sanitariy. 2016; 95(11):1055-1058.
  3. Methodical instruction on hygienic assessment of new pesticides. Kiev. 1988; 210 p.
  4. Kagan Y.S. General pesticide toxicology. – Kiev. Zdorovie. 1981; 176 р.
  5. Rylova M.L. Method of exploring chronic action of adverse environment factors in theexperiment. L., Medicine.1964; 227 р.
  6. Pavlenko S.M. Application of summation-threshold index in toxicological experiment on white rats. Methodic of sanitary-toxicological experiment: scientific works collections of MNIIG named after F.F.Erisman. M. 1975; 5-
  7. Methodical recommendation on using reaction of animals’ behaviour in toxicological researches for hygienic standartization. Kiev. 1980; 47 p.
  8. Anokhin P.K. Surveys on functional systems physiology.M. Medicine. 1975; 448р.
  9. Clinical biochemistry: Manual for laboratory doctors. Kalb V.G., Kamyshnikov V.S. Minsk, Byelorussia. 1976; 311p.

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版权所有 © Rakitskii V.N., Еpishina T.M., Chkhvirkiya E.G., Sinitskaya T.A., Mukhina Е.A., 2019


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